Benchmarking the Intel®Xeon®Platinum 8160 Processor

This report presents a set of results for different microbenchmarks and applications on the Intel Xeon Platinum8160 Processor, formerly known as Skylake. For simplicity, we will use both Skylake and SKX to refer to this processor. We use the Skylake nodes that will be available in Stampede2. This systemwill provide Intel Knights Landing and Skylake chips interconnected by a 100 Gb/sec Intel Omni-Path (OPA) network with a fat tree topology. The peak performance of the system will be 18 PF.Texas Advanced Computing Center (TACC

CyberWalk : a web-based distributed virtual walkthrough environment

A distributed virtual walkthrough environment allows users connected to the geometry server to walk through a specific place of interest, without having to travel physically. This place of interest may be a virtual museum, virtual library or virtual university. There are two basic approaches to distribute the virtual environment from the geometry server to the clients, complete replication and on-demand transmission. Although the on-demand transmission approach saves waiting time and optimizes network usage, many technical issues need to be addressed in order for the system to be interactive. CyberWalk is a web-based distributed virtual walkthrough system developed based on the on-demand transmission approach. It achieves the necessary performance with a multiresolution caching mechanism. First, it reduces the model transmission and rendering times by employing a progressive multiresolution modeling technique. Second, it reduces the Internet response time by providing a caching and prefetching mechanism. Third, it allows a client to continue to operate, at least partially, when the Internet is disconnected. The caching mechanism of CyberWalk tries to maintain at least a minimum resolution of the object models in order to provide at least a coarse view of the objects to the viewer. All these features allow CyberWalk to provide sufficient interactivity to the user for virtual walkthrough over the Internet environment. In this paper, we demonstrate the design and implementation of CyberWalk. We investigate the effectiveness of the multiresolution caching mechanism of CyberWalk in supporting virtual walkthrough applications in the Internet environment through numerous experiments, both on the simulation system and on the prototype system

Collider-independent top quark forward-backward asymmetries: Standard model predictions

We compute, for top quark pair production at the Tevatron and the Large Hadron Collider, the collider-independent forward-backward asymmetries defined by [Aguilar-Saavedra and Juste, Phys. Rev. Lett. 109, 211804 (2012).] in the standard model at next-to-leading order in QCD, including also electromagnetic and weak corrections.The work of J.A.A.S. has been supported by MICINN by projects FPA2006-05294 and FPA2010-17915, Junta de Andalucía (FQM 101, FQM 03048 and FQM 6552) and Fundação para a Ciência e Tecnologia (FCT) project CERN/FP/123619/2011. The work of W.B. was supported by DFG, SFB TR9 and that of Z.G. Si by NSFC and by Natural Science Foundation of Shandong Province

Dynamic Adaptable Asynchronous Progress Model for MPI RMA Multiphase Applications

Casper is a process-based asynchronous progress model for MPI one-sided communication on multi- and many-core architectures. The one-sided communication is not truly one-sided in most MPI implementations: the target process still relies on software progress to complete incoming operations. Casper allows the user to specify an arbitrary number of cores dedicated to background ghost processes and transparently redirects the RMA operations to ghost processes by utilizing the PMPI redirection and MPI-3 shared-memory technologies. Although Casper benefits applications that suffer from lack of asynchronous progress, the operation redirection design might not support complex multiphase applications effectively, which often involve dynamically changing communication density and computing workloads. In this paper, we present an adaptive mechanism in Casper to address the limitation of static asynchronous progress in multiphase applications. We exploit two adaptive strategies, a user-guided strategy and a fully transparent and automatic strategy based on self-profiling and prediction, to dynamically reconfigure the asynchronous progress in Casper according to real-time performance characteristics during multiphase execution. We evaluate the adaptive approaches in both microbenchmarks and a real quantum chemistry application suite, NWChem, on the Cray XC30 supercomputer and an Intel Omni-Path cluster.This material was based upon work supported by the U.S. Dept. of Energy, Office of Science, Advanced Scientific Computing Research (SC-21), under contract DE-AC02- 06CH11357. The experimental resources for this paper were provided by the National Energy Research Scientific Computing Center (NERSC) on the Edison Cray XC30 supercomputer and by the Laboratory Computing Resource Center on the Bebop cluster at Argonne National Laboratory. Antonio J. Peña is co-financed by the Spanish Ministry of Economy and Competitiveness under Juan de la Cierva fellowship number IJCI-2015-23266.Peer ReviewedPostprint (author's final draft

Effect of the N-based ligands in copper complexes for depolymerisation of lignin

Several organic soluble N-based ligands and their copper complexes were firstly investigated as catalysts to depolymerise organosolv lignin in the organic solvent, dimethylformamide (DMF) and an ionic liquid (1-ethyl-3-methylimidazolium xylenesulfonate, [emim][ABS]). The results of screening depolymerisation reactions in DMF and [emim][ABS] showed that all the copper–amine complexes catalysed lignin depolymerisation more efficiently in ionic liquids than in DMF. Among the seven types of ligands, copper complexes with two types of ligands (E)-N-(pyridin-2-ylmethylene)aniline and (E)-4-methoxy-N-(pyridin-2-ylmethylene)aniline depolymerised the lignin more efficiently than the others. These two copper complexes with the N-based ligand were further studied to determine the most efficient conditions for the depolymerisation of the lignin. The most effective depolymerisation by conditions involved treatment at 180 °C for 12 h in [emim][ABS]. Cyclic voltammetric studies were carried out to investigate the reversible potential associated with the copper centers of their complexes with these N-based ligands. The results suggest that two types of ligands have more positive reversible potentials than those of other copper complexes

Chest imaging features of patients afflicted with Influenza A (H1N1) in a Malaysian tertiary referral centre

This is a retrospective descriptive study of the chest imaging findings of 118 patients with confirmed A(H1N1) in a tertiary referral centre. About 42% of the patients had positive initial chest radiographic (CXR) findings. The common findings were bi-basal air-space opacities and perihilar reticular and alveolar infiltrates. In select cases, high-resolution computed tomography (CT) imaging showed ground-glass change with some widespread reticular changes and atelectasis

Risk profiling of soil-transmitted helminth infection and estimated number of infected people in South Asia : a systematic review and Bayesian geostatistical analysis

In South Asia, hundreds of millions of people are infected with soil-transmitted helminths (Ascaris lumbricoides, hookworm, and Trichuris trichiura). However, high-resolution risk profiles and the estimated number of people infected have yet to be determined. In turn, such information will assist control programs to identify priority areas for allocation of scarce resource for the control of soil-transmitted helminth infection.; We pursued a systematic review to identify prevalence surveys pertaining to soil-transmitted helminth infections in four mainland countries (i.e., Bangladesh, India, Nepal, and Pakistan) of South Asia. PubMed and ISI Web of Science were searched from inception to April 25, 2019, without restriction of language, study design, and survey date. We utilized Bayesian geostatistical models to identify environmental and socioeconomic predictors, and to estimate infection risk at high spatial resolution across the study region.; A total of 536, 490, and 410 georeferenced surveys were identified for A. lumbricoides, hookworm, and T. trichiura, respectively. We estimate that 361 million people (95% Bayesian credible interval (BCI) 331-395 million), approximately one-quarter of the South Asia population, was infected with at least one soil-transmitted helminth species in 2015. A. lumbricoides was the predominant species. Moderate to high prevalence (>20%) of any soil-transmitted helminth infection was predicted in the northeastern part and some northern areas of the study region, as well as the southern coastal areas of India. The annual treatment needs for the school-age population requiring preventive chemotherapy was estimated at 165 million doses (95% BCI: 146-185 million).; Our risk maps provide an overview of the geographic distribution of soil-transmitted helminth infection in four mainland countries of South Asia and highlight the need for up-to-date surveys to accurately evaluate the disease burden in the region

Neutrophils in cancer: neutral no more

Neutrophils are indispensable antagonists of microbial infection and facilitators of wound healing. In the cancer setting, a newfound appreciation for neutrophils has come into view. The traditionally held belief that neutrophils are inert bystanders is being challenged by the recent literature. Emerging evidence indicates that tumours manipulate neutrophils, sometimes early in their differentiation process, to create diverse phenotypic and functional polarization states able to alter tumour behaviour. In this Review, we discuss the involvement of neutrophils in cancer initiation and progression, and their potential as clinical biomarkers and therapeutic targets